Eisai starts phase 3 trials for second Alzheimer's drug after first's failure

* Eisai begins BAN2401 trials, confident in amyloid beta target

* Stock untraded as sell orders outnumber buy orders by 40 times

* Four Alzheimer's drugs approved in 20 years; 146 attempts failed (Adds comment from Eisai and analyst, background)

By Takashi Umekawa

TOKYO, March 22 (Reuters) - Eisai Co Ltd on Friday said it has begun phase 3 clinical trials of Alzheimer's treatment BAN2401, a day after the Japanese drugmaker and U.S. partner Biogen Inc scrapped trials for another Alzheimer's drug, aducanumab.

The aducanumab announcement knocked $18 billion of Biogen's stock value. On Friday, Eisai was untraded, flooded with sell orders at 7,565 yen, almost 17 percent lower than its previous close.

The demise of aducanumab came after independent experts determined the trials had little hope of succeeding, marking the latest setback in the quest to treat a mind-wasting disease that affects 5.7 million people in the United States alone.

Eisai and Biogen were jointly developing three experimental drugs for Alzheimer's: aducanumab, BAN2401 and elenbecestat, all designed to target the brain-destroying protein beta amyloid.

"As we have believed aducanumab was the best hope for treating Alzheimer's, ending its trials is big negative surprise," said analyst Motoya Kohtani at Nomura Securities.

BAN2401 has been met with scepticism since the partners reported promising but confusing 18-month results in July. Yet Eisai remains confident in its continued development.

"We still believe that amyloid beta hypothesis is potentially the right approach for the treatment of Alzheimer's disease," an Eisai spokesman told Reuters.

Eisai will conduct phase 3 trials of BAN2401 involving 1,566 patients with mild cognitive impairment or mild Alzheimer's disease dementia with confirmed amyloid accumulation.

Alzheimer's treatments are known as being particularly difficult to develop, as both diagnosis and the recruitment of appropriate trial participants are challenging.

From 1998 through 2017, only four treatments have been approved with another 146 attempts resulting in failure, according to the Adis R&D Insight database.

Alzheimer's is the most common form of dementia. In Japan, the government estimates there will be 7 million dementia sufferers in 2025, from 4.6 million in 2012.

(Reporting by Takashi Umekawa, Sam Nussey and Chang-Ran Kim; Editing by David Dolan and Christopher Cushing)

2019-03-22 07:50:33

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